Inhibition of inner ear macrophage phagocytosis alleviates cisplatin-induced ototoxicity.

ABSTRACT: The immune response is considered a significant pathological mechanism of inner ear damage. However, the role of macrophages, as key components of immune cells, in immunity in the inner ear remains elusive. Evidence from other organs indicates that phagocytosis, a core function of macrophages, plays a crucial role in maintaining homeostasis, development, and tissue repair regeneration. However, it has rarely been studied in the inner ear. This field may currently hold new insights. In this study, we aimed to investigate the immunological contribution of resident macrophages in the inner ear to cisplatin-induced ototoxicity. By using clodronate liposomes and cytochalasin to deplete macrophages or inhibit macrophage phagocytosis locally, we first elucidated the dynamic changes in the immune

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12311119 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature