Neural Plasticity Induced by Working Memory Training: Insights From Cortical Microstructure and Transcriptional Profiles.

ABSTRACT:

Aims

To investigate the effects of an 8-week standardized computerized working memory training (WMT) program on cortical microstructure, morphometric similarity network (MSN) changes, and associated genetic factors in healthy adults.

Methods

A total of 76 participants were divided into WMT and control groups. Cortical morphological measurements, including cortical thickness (CT) and fractional dimensions (FD), were measured. MSN changes based on CT and FD measures were analyzed. Additionally, partial least squares (PLS) analysis was conducted to investigate the relationship between critical microstructural alterations and gene transcript expression levels.

Results

The WMT group exhibited reduced response times for updating, switching functions, and phonological loop t

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12311235 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature