PCP4 inhibits the progression of prostate cancer through Ca²⁺/CAMKK2/AMPK/AR pathway.

ABSTRACT:

Background

The development of prostate cancer (PCa) remains a major health threat for men worldwide. Calcium/Calmodulin signaling pathway has been implicated to the initiation and progression of diverse human cancers. Loss or downregulation of Purkinje cell protein 4 (PCP4), is frequently observed in some prostate cancer patients, particularly those with castration-resistant prostate cancer (CRPC).

Methods

Public datasets were used to analyze PCP4 expression and the relationship between PCP4 expression and clinicopathological characteristics of PCa patients. Gain- and loss-of-function studies in PCa cell lines and mouse models were performed to characterize the role of PCP4 in tumor progression. A series of molecular and biochemical experiments were carried out in PCa cell l

SUBMITTER: Jia W 

PROVIDER: S-EPMC12311239 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature