Peripheral Biomarker Signatures in Rheumatoid Arthritis-Associated Interstitial Lung Disease.

ABSTRACT:

Objective

Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA-ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA-ILD discrimination beyond clinical and genetic risk factors.

Methods

We performed a cross-sectional study of participants in the Veterans Affairs Rheumatoid Arthritis Registry. ILD was validated through systematic record review. Autoantibodies (n = 14), proinflammatory cytokines/chemokines (n = 36), adipokines (n = 3), alarmins (n = 3), and matrix metalloproteinases (n = 9) were measured from banked serum or plasma. MUC5B rs35705950 genotyping was obtained via microarray. P

SUBMITTER: Wheeler AM 

PROVIDER: S-EPMC12311258 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature