Change points for dynamic biomarkers in the Alzheimer's disease pathological cascade: A 30-year cohort study.

ABSTRACT:

Introduction

This study aimed to delineate trajectories of biomarkers-amyloid beta (Aβ), phosphorylated tau, neurodegeneration, and inflammation-and to identify change points along these trajectories.

Methods

Longitudinal data were collected over 30 years from 349 cognitively unimpaired individuals enrolled in the Biomarkers for Older Controls at Risk for Dementia study. Piecewise regression models were used to identify change points in cerebrospinal fluid biomarkers, brain magnetic resonance imaging volumes, and a composite measure of global cognition.

Results

Eighty-two participants progressed to mild cognitive impairment or dementia during the follow-up period. Change points were identified in years prior to clinical symptom onset: Aβ at -17.1 years, phosphorylated

SUBMITTER: Uchida Y 

PROVIDER: S-EPMC12311614 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature