Luminescent Nanocomposite SiO₂/EuTTA/ZIF‑8 Loaded with Uvaol: Synthesis, Characterization, Anti-Inflammatory Effects, and Molecular Docking Analysis.

ABSTRACT: Asthma is a chronic inflammatory respiratory condition that requires innovative approaches for effective drug delivery. Uvaol, a natural triterpene with potent anti-inflammatory effects, holds promise for asthma treatment. However, its low bioavailability limits its therapeutic applications. To overcome this challenge, we synthesized a europium-based nanocomposite (SiO₂/EuTTA/ZIF-8) to enhance uvaol delivery. The nanomaterials were characterized using UV-visible absorption spectroscopy, fluorescence analysis, and molecular docking simulations. Drug loading and release studies were conducted in PBS to evaluate encapsulation efficiency and controlled release properties. Cytotoxicity assays were performed to assess biocompatibility, and molecular docking was used to analyze interac

SUBMITTER: Viana RS 

PROVIDER: S-EPMC12311653 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature