Magnetic Nanoparticle Capture and Quantum Dot Labeling for Rapid and Quantitative Detection of Methicillin-Resistant.

ABSTRACT: The increasing incidence of drug-resistant bacterial strains, such as methicillin-resistant (MRSA), poses a significant threat to public health owing to their high morbidity and mortality rates. Conventional methods for MRSA detection are expensive and time-consuming, necessitating advanced technological solutions. This study aimed to develop a direct detection strategy for MRSA by using magnetic nanoparticles (MNPs) as capture probes and quantum dots (QDs) as fluorescent detection probes. MNP capture probes were prepared by the coprecipitation of Fe₃O₄ NPs, followed by co-condensation to obtain amine-functionalized silica coatings on Fe₃O₄ NPs (amine-Si@MNPs). Carboxyl modification of amine-Si@MNPs was achieved via the hydrolytic cleavage of suc

SUBMITTER: Satheesan N 

PROVIDER: S-EPMC12311688 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature