The Role of c‑Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma.

ABSTRACT: Melanoma stands as an increasingly pressing health concern. Enhanced mitochondrial metabolism has been reported in melanoma cells that survived treatment with traditional therapeutics, including cytidine analogs like gemcitabine (GEM). These findings suggest that chemotherapeutic drugs may play dual roles in promoting both cell survival and cell death, although the underlying mechanisms require further investigation. Herein, we conducted proteomics analysis on GEM-treated melanoma cells and found a drug-induced activation of DNA damage response and apoptosis, along with cell cycle arrest. Additionally, GEM treatment significantly altered protein networks related to mitochondrial ribosomal activity, the electron transport chain, and translation. Furthermore, we reported an upregulation of t

SUBMITTER: Sensenbach S 

PROVIDER: S-EPMC12311696 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature