Role of Phospholipids on Drug Dissolution in Polymer Solid Dispersions Prepared by Hot-Melt Extrusion.

ABSTRACT: The development of solid dispersions (SDs) has gained increased attention in recent decades, leading to successful delivery systems for various marketed products. In general, combinations of polymers and lipids in SD formulations have shown promising results in reducing the disadvantages associated with the isolated use of hydrophilic excipients such as copovidone (COP) and Soluplus (SLP). This study investigated the influence of the phospholipid (soy phosphatidylcholine, PPC, 15 and 30%, w/w) on the dissolution performance of drug-polymer SDs prepared by hot melt extrusion. A low-solubility model drug (ritonavir, RTV) was selected for the study. A complete drug amorphization was observed for all extrudates despite the PPC presence. However, PPC improved the process yield without requiring

SUBMITTER: de Carvalho DM 

PROVIDER: S-EPMC12311706 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature