Nutritional Supplementation Benefits in under Developmental Disruption and Stress Conditions.

ABSTRACT: Autism spectrum disorder (ASD) is a developmental and neurological condition that impacts an individual's behavior, communication, social interaction, and learning abilities. This disease is complex and involves different mechanisms, and therefore, modeling is a major challenge. Some features can be reproduced in different animal models to investigate therapeutic approaches. Here, we proposed a new simple model to induce development delay by using the nematode and dithiothreitol (DTT) as a chemical agent. In order to investigate a complementary treatment, a commercial supplement and its isolated components (vit. B12, B1, B6, and B9), curcumin, and palmitoylethanolamide (PEA) were used to revert the oxidative stress, development impairments, and metabolomic changes caused by DTT. Furthermor

SUBMITTER: Avila DS 

PROVIDER: S-EPMC12311710 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature