Transgender-Affirming Hormone Therapies, QT Prolongation, and Cardiac Repolarization.

ABSTRACT:

Importance

Transgender women (assigned male at birth) usually take antiandrogens associated with estrogens (or are castrated) to induce feminization, whereas transgender men (assigned female at birth) take testosterone to induce masculinization. However, the cardiovascular outcomes of these gender-affirming hormone therapies (GAHTs) remain poorly studied.

Objective

To examine the association between GAHT intake and cardiac repolarization alterations on electrocardiography in transgender individuals.

Design, setting, and participants

In this cohort study, data from a prospective cohort of adult transgender individuals from a single center in France were collected from January 1, 2021, to January 1, 2023. GAHT consisted of injectable testosterone in transgender men and

SUBMITTER: Grouthier V 

PROVIDER: S-EPMC12311718 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature