A retrospective study of laryngeal squamous cell carcinoma and the significance of the PIK3CA mutation for survival.

ABSTRACT: The aim of this study was to assess clinical features, outcomes and survival in patients with laryngeal squamous cell carcinoma (LSCC) and to associate mutations in cancer-related genes with clinical outcomes. A total of 88 patients with LSCC who underwent curative treatment between April 2008 and May 2024 at Hokuto Hospital (Obihiro, Japan) were included. Mutations in targeted regions of 160 cancer-related genes were analyzed using next-generation sequencing (NGS). LSCC was of glottic type in 65 patients (74%) and supraglottic type in 23 patients (26%). As initial treatment, laryngomicrosurgery, radiotherapy (RT) alone, RT with transoral administration of S-1, concurrent chemoradiotherapy with cisplatin, and total laryngectomy were performed in 6 (7%), 48 (55%), 13 (15%), 8 (9%), and 13 (

SUBMITTER: Kubota A 

PROVIDER: S-EPMC12311762 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature