Influenza-Associated Acute Necrotizing Encephalopathy in US Children.

ABSTRACT:

Importance

Acute necrotizing encephalopathy (ANE) is a rare, but severe, neurologic condition for which epidemiologic and management data remain limited. During the 2024-2025 US influenza season, clinicians at large pediatric centers anecdotally reported an increased number of children with influenza-associated ANE, prompting this national investigation.

Objective

To understand the clinical presentation, interventions, and outcomes among US children diagnosed with influenza-associated ANE.

Design, setting, and participants

This study was a multicenter case series of children diagnosed with ANE with longitudinal follow-up. A call for cases was issued via academic societies, public health agencies, and by directly contacting pediatric specialists at 76 US academic cente

SUBMITTER: Influenza-Associated Acute Necrotizing Encephalopathy (IA-ANE) Working Group 

PROVIDER: S-EPMC12311823 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature