Modeling the Impact of Vaccine Dose Prioritization Strategies During the 2022 Mpox Outbreak.

ABSTRACT: Early in the 2022 mpox outbreak, the U.S. recommendation was to administer two doses of the JYNNEOS® vaccine 4 weeks apart. However, because of limited vaccine supply, New York City (NYC) prioritized single dose vaccination. We estimated mpox cases averted by this strategy compared to strategies that prioritized 2-dose vaccination for a smaller portion of the population. We fit a network transmission model to incident mpox cases in NYC. Model output consisted of predicted cases over time when vaccine doses were administered with the 'first-dose priority' strategy, compared with counterfactual simulations where doses were administered to those eligible for a second dose ahead of those waiting for a first dose ('intermediate' strategy), or where individuals were pre-allocated full courses of

SUBMITTER: Clay PA 

PROVIDER: S-EPMC12311848 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature