Baseline Stability of Thermally Hydrosilated Porous Silicon with Zwitterionic Antifouling Polymer Coating for Biosensing Applications.

ABSTRACT: Porous silicon (PSi)-based biosensors are a promising platform for quantitative rapid diagnostics, but they have not broadly realized clinically relevant limits of detection due, in part, to poor baseline stability. Baseline instability can be attributed to two major physicochemical challengeshydrolysis of PSi in aqueous solutions and fouling by unwanted biological species, both of which can obscure the detection of target molecules at low concentrations. In this work, PSi was thermally hydrosilated with vinylbenzyl chloride (VBC) to incorporate hydrolytically stable Si-C bonding and to provide an attached alkyl halide termination for further chemistry. Subsequent grafting of zwitterionic poly-(sulfobetaine methacrylate) (SBMA) from this PSi-VBC layer by surface-initiated atom-transfer ra

SUBMITTER: Smail SM 

PROVIDER: S-EPMC12311861 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature