Profiling of Anti-FVIII Antibodies in Acquired Haemophilia A: 'Insights into Domain Specificity, Isotype Variability, and Clinical Correlations'.

ABSTRACT:

Introduction

Acquired haemophilia A (AHA) is a rare autoimmune disorder caused by autoantibodies against coagulation factor VIII (FVIII), resulting in significant bleeding risks.

Aim

To characterize the anti-FVIII antibody profile in AHA patients by assessing isotypes, subclasses, and correlations with key clinical parameters.

Methods

Eighty AHA patients were retrospectively analysed by assessing FVIII inhibitor levels, antibody isotypes (IgG, IgA, IgM), IgG subclasses, and domain specificity using a bead-based assay. Clinical data were correlated with antibody profiles. IgG domain profiles were compared with a congenital haemophilia A (CHA) cohort.

Results

The cohort had a median age of 74 years, with 60% males. Idiopathic cases accounted for 67%, and 17% had

SUBMITTER: Berkemeier AC 

PROVIDER: S-EPMC12311880 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature