A Global Cross-Sectional Database Study of Low Dose FVIII SHL Prophylaxis in Haemophilia A.

ABSTRACT:

Introduction

Haemophilia treatment is costly and only 25% of patients receive adequate care. Although not optimal, Factor VIII (FVIII) low-dose prophylaxis (LDP) may reduce annual joint bleeding rates. Understanding FVIII usage, collected through the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) platform, and its association with Gross National Income per capita (GNI) and Universal Health Coverage index (UHCI) may provide insights in global disparities.

Aims

To provide insights in FVIII use to advocate for LDP in low-income countries by providing: (i) statistical summary of FVIII usage, LDP prevalence, GNI and UHCI in WAPPS-Hemo in 2017-2023; (ii) estimation of the relationship between LDP probability (P_LDP) and GNI/UHCI for children (≤

SUBMITTER: Hajducek DM 

PROVIDER: S-EPMC12311883 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature