Clotting Factor Concentration During Menstrual Phases in Women With and Without Heavy Menstrual Bleeding: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Cyclic sex-hormone fluctuation impacts clotting factor concentrations, being lowest during the follicular phase of the menstrual cycle. This pattern is unexplored in women with heavy menstrual bleeding (HMB), but potentially affects the timely diagnosis of underlying bleeding disorders.

Aim

Comparing clotting factor fluctuation in the follicular versus luteal phase, between women with and without HMB.

Methods

A PubMed/MEDLINE systematic review on HMB and clotting factors. Articles reporting clotting factor concentrations in premenopausal women with and without HMB were included, categorized by follicular or luteal phase if the sampling moment was specified. A meta-analysis was performed and the effect of HMB on (cyclic) clotting factor concentrations was as

SUBMITTER: de Vaan A 

PROVIDER: S-EPMC12311891 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature