NMR Reaction Monitoring Robust to Spectral Distortions.

ABSTRACT: Nuclear magnetic resonance spectroscopy (NMR) is one of the most potent analytical chemistry methods, providing unique insight into molecular structures. Its noninvasiveness makes it a perfect tool for monitoring chemical reactions and determining their products and kinetics. Typically, the reactions are monitored by a series of ¹H NMR spectra acquired at regular time intervals. Even such a straightforward approach, however, often suffers from several problems. In particular, the reaction may cause sample inhomogeneity, resulting in a nonhomogenous magnetic field and distorted spectral lineshapes. When the studied process is fast, hardware correction (shimming and locking) cannot be applied on the fly, and the spectral quality degrades over the course of the reaction. Moreover,

SUBMITTER: Domzal B 

PROVIDER: S-EPMC12311900 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature