Utility and real-world clinical outcomes of next-generation sequencing in advanced non-small-cell lung cancer in the South Indian population.

ABSTRACT:

Background

Next-generation sequencing (NGS) is an advanced sequencing technology that enables rapid sequencing of numerous DNA strands and performs simultaneous analysis of various genes and diverse genomic characteristics. While there is a lack of substantial evidence available, the extent to which NGS may improve clinical outcomes among cancer patients in a real-world scenario remains uncertain.

Objective

To investigate the clinical utility of NGS in patients treated with advanced non-small cell lung cancer (NSCLC) and its impact on real-world clinical outcomes, treated with targetable or non-targetable agents.

Materials and methods

This was a prospective observational study conducted in 322 participants distributed over 2 broad categories- NGS and non-NGS. The NGS

SUBMITTER: Anoop TM 

PROVIDER: S-EPMC12311926 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature