Prediction of early distant brain failure after stereotactic radiotherapy for brain metastases.

ABSTRACT:

Background

Stereotactic radiotherapy (SRT) is the main treatment for patients with 1 to 3-5 brain metastases (BMs) but with the compromise of a higher risk of distant brain failure (DBF) in comparison with whole brain radiotherapy. Early DBF has a significant negative impact on overall survival (OS). We propose to build and validate a prediction model of early DBF.

Methods

Early DBF was defined as the appearance of unknown BMs on the first post-SRT magnetic resonance imaging (MRI). A nomogram was built for the prediction of early DBF using patients from a cohort of 537 SRT courses. The nomogram was evaluated for early DBF classification using the chi-squared test. Prediction of DBF-free survival and OS was tested using Kaplan-Meier curves and the log-rank test. The model was

SUBMITTER: Morjani M 

PROVIDER: S-EPMC12311934 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature