Bevacizumab alternating chemotherapy for improving the survival of patients with recurrent high-grade glioma.

ABSTRACT:

Background

High-grade glioma (HGG) is an aggressive tumor for which there are no effective therapies at recurrence, especially for isocitrate dehydrogenase (IDH)-wild-type glioblastoma. This retrospective study compared survival outcomes between patients receiving bevacizumab alternating chemotherapy (BAC) and those receiving bevacizumab (BEV) alone.

Methods

We collected data from 95 adult patients with rHGG who were treated at our institute between January 2018 and August 2023. The patients were divided into 3 groups based on treatment and glioma grade: BAC regimen to treat grade 3 gliomas (n = 23), BAC regimen to treat grade 4 gliomas (n = 29), and treatment with BEV alone (n = 43). The BAC regimen included 2 cycles of etoposide + carboplatin, followed

SUBMITTER: Liu PC 

PROVIDER: S-EPMC12311935 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature