Regional Molecular Signature of the Symptomatic Atherosclerotic Carotid Plaque.

ABSTRACT:

Background

Many studies have explored molecular markers of carotid plaque development and vulnerability to rupture, usually having examined whole carotid plaques. However, there are regional differences in plaque morphology and known shear-related mechanisms in areas surrounding the lipid core.

Objective

To determine whether there are regional differences in protein expression along the long axis of the carotid plaque and how that might produce gaps in our understanding of the carotid plaque molecular signature.

Methods

Levels of 7 inflammatory cytokines (IL-1β, IL-6, IL-8, IL-10, IL-12 p70, IFN-γ, and TNF-α) and caspase-3 were analyzed in prebifurcation, bifurcation, and postbifurcation segments of internal carotid plaques surgically removed from symptomatic and asym

SUBMITTER: Caparosa EM 

PROVIDER: S-EPMC12311974 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature