S-GMAS: Genome-Wide Mediation Analysis With Brain Subcortical Shape Mediators.

ABSTRACT: Mediation analysis is widely utilized in neuroscience to investigate the role of brain image phenotypes in the neurological pathways from genetic exposures to clinical outcomes. However, it is still difficult to conduct mediation analyses with whole genome-wide exposures and brain subcortical shape mediators due to several challenges including (i) large-scale genetic exposures, that is, millions of single-nucleotide polymorphisms (SNPs); (ii) nonlinear Hilbert space for shape mediators; and (iii) statistical inference on the direct and indirect effects. To tackle these challenges, this paper proposes a genome-wide mediation analysis framework with brain subcortical shape mediators. First, to address the issue caused by the high dimensionality in genetic exposures, a fast genome-wide associ

SUBMITTER: Ding S 

PROVIDER: S-EPMC12311987 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature