Evaluating polygenic risk score prediction performance for Alzheimer's disease in a population-based Hispanic cohort using single- and multi-ancestry models.

ABSTRACT:

Background

The Polygenic risk score (PRS) is effective in predicting Alzheimer's Disease (AD) risk among Europeans but remains understudied in Hispanics. Genome-wide association studies (GWAS) based on multiple ancestries can improve PRS prediction. We used GWAS data from the largest available African, European, and Hispanic populations and performed PRS analyses using novel methodologies to evaluate the performance of single- and multi-ancestry PRS models in predicting AD risk among Hispanic population.

Methods

Prediction performance of Apolipoprotein-E (APOE), single-ancestry PRS, and multi-ancestry PRS derived from GWAS-focused and method-focused approaches to clinical AD, incident AD, and cognition and were evaluated in 2961 Hispanic people from two large studies.

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12312067 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature