Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors.

ABSTRACT: Chronic stress often has deleterious effects leading to the development of psychiatric diseases. The gut-brain axis represents a novel avenue for stress research. The negative effects of stress on the gut physiology have been well-described, whereas the pathways whereby stress controls microbial composition to modulate behaviors remains mainly unknown. We discovered that vasoactive intestinal peptide (VIP) activation promoted stress-induced microbial changes leading to increased infiltration of T helper (Th) 17 cells and microglial activation in the hippocampus and depressive-like behaviors, uncovering a close crosstalk between intestinal VIPergic release and the gut microbiota during stress and providing a new interaction between the nervous system and the gut microbiome after stress. Neu

SUBMITTER: Medina-Rodriguez EM 

PROVIDER: S-EPMC12312121 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature