High-Density Inverted Micellar Intermediates Promote Membrane Fusion of Cationic Liposomes in Drug Delivery.

ABSTRACT: Liposomes have become increasingly popular as carriers for pharmaceutically relevant molecules such as nucleic acids, proteins, or anticancer drugs. The bottleneck in delivering such vehicles is their inefficient endosomal uptake by target cells. To bypass endosomal degradation and enhance delivery efficiency, fusogenic liposomes have been developed. They fuse with extraordinary efficiency with the plasma membrane of mammalian cells and deliver their cargo directly into the cell cytoplasm. Here, we set out to decipher the key to membrane fusion and optimize the liposomal composition accordingly. Special focus has been placed on identifying the intrinsic phase properties of these liposomes. Therefore, giant and small cationic liposomes with outstandingly high membrane fusion efficiency were

SUBMITTER: Kolasinac R 

PROVIDER: S-EPMC12312148 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature