Selective Modulation of Lipid Langmuir Monolayers by Methyl Dehydrodieugenol: Insights into Its Interaction with Compressibility-Modulating Lipid Interfaces for Antiprotozoal Applications.

ABSTRACT: This study investigates the interaction of methyl dehydrodieugenol (MDHDE) with model lipid monolayers to elucidate its potential as a membrane-targeting therapeutic agent. Langmuir monolayer experiments were conducted using dioleoylphosphatidylcholine (DOPC), dioleoylphosphatidylethanolamine (DOPE), and cholesterol to mimic the compressible and condensed states of protozoal and mammalian membranes. Surface pressure-area isotherms revealed that MDHDE reduced the molecular packing density of the lipids at biologically relevant surface pressures, suggesting attractive interactions at the molecular level. While the surface compressional modulus decreased for all monolayers, the dilatational elasticity measurements indicated an increase in the elastic character of the DOPC monolayer upon MDHDE

SUBMITTER: Berllini GT 

PROVIDER: S-EPMC12312162 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature