Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates.

ABSTRACT: Effective vaccines elicit B cell clonal expansion in germinal centers (GCs) that produce memory B cells and antibody secreting plasma cells. Studies in mice indicate that, whereas the plasma cell compartment is enriched for cells producing high affinity antibodies, the memory pool is more diverse and contains only a relatively small proportion of higher affinity cells. Upon boosting, murine memory B cells producing high affinity antibodies tend to develop into plasma cells but few if any re-enter GCs. However, mice live for only a few weeks in nature, and in keeping with the rather limited requirement for immune memory, this compartment comprises only 1-2% of all B cells. In contrast, memory accounts for nearly 50% of all B cells in primates. Here we examine memory and GC B cell responses

SUBMITTER: Deimel LP 

PROVIDER: S-EPMC12312172 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature