Immunoinformatic design of chimeric multiepitope vaccine for the prevention of human metapneumovirus (hMPV).

ABSTRACT:

Background

Human metapneumovirus (hMPV) is a significant etiological agent of acute respiratory infections in children and immunocompromised individuals. Despite its growing clinical impact, no approved vaccines or targeted antiviral therapies are currently available.

Methods

An immunoinformatic approach was employed to design a chimeric multi-epitope vaccine candidate against hMPV. Conserved and virulence-associated proteins were analyzed to predict highly antigenic B cell, cytotoxic T lymphocyte (CTL), and helper T lymphocyte (HTL) epitopes. The selected epitopes were screened for antigenicity, non-toxicity, non-allergenicity, and lack of homology to human proteins. The final construct included six B cell epitopes, six CTL epitopes, and two HTL epitopes, linked with approp

SUBMITTER: Ehsasatvatan M 

PROVIDER: S-EPMC12312241 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature