NR1I3 modulates Wnt signaling to promote anterior-posterior axis patterning.

ABSTRACT:

Background

Regeneration of missing structures and tissue turnover during homeostasis require positional information to instruct the reestablishment of body axes and to specify new cells to replace aged tissues. Planarians present an ideal model for positional information studies, as they can regenerate any missing parts and replace aged cells during tissue turnover. Position control genes (PCGs) characterized by constitutive and regional expression in planarians have been identified to instruct regeneration and tissue turnover. However, it is not entirely understood how these genes coordinate in maintaining proper tissue structures.

Results

Here we report that NR1I3, a nuclear receptor family transcription factor, functions in the establishment and maintenance of the anterop

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12312329 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature