Ultrasound initiated tumor catalytic PANoptosis by mesoporous piezoelectric nanocatalysts.

ABSTRACT:

Background

PANoptosis has been identified as a robust inflammatory cell death pathway triggered upon host defense against invaded pathogens such as bacteria and viruses, however, pathogen-free tumor PANoptosis has not been achieved yet. Reactive oxygen and nitrogen species capable of inducing robust and diverse cell death pathways such as pyroptosis, apoptosis, and necroptosis are supposed to be the potential triggers for tumor PANoptosis by ultrasound (US)-controlled sono-piezodynamic therapy.

Methods

S-nitrosothiols (SNO)-zinc peroxide (ZnO₂)@cyclic dinucleotide (CDN)@mesoporous tetragonal barium titanate (mtBTO) nanoparticles (NZCB NPs) were synthesized by hydrothermal method with subsequent annealing, in situ growth, and finally surface functionalization. Scan

SUBMITTER: Xu XS 

PROVIDER: S-EPMC12312345 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature