Relationship between time-weighted average anion gap and mortality in septic shock patients: a retrospective analysis of the MIMIC-IV database.

ABSTRACT:

Background

The relationship between the anion gap (AG) level, represented by the time-weighted average AG (TWA-AG), and outcomes of septic shock patients remains unclear. This study aimed to investigate the relationship between TWA-AG and all-cause mortality in septic shock patients.

Methods

This study included septic shock patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Participants were categorized into four quartiles based on their TWA-AG values. The primary outcome was 30-day mortality, and the secondary outcomes were in-hospital and 1-year mortality. Cox regression models, logistic regression models, and restricted cubic spline analyses were conducted to evaluate the relationship between TWA-AG and mortality.

Results

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SUBMITTER: Zhang L 

PROVIDER: S-EPMC12312503 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature