Extracellular vesicles from bronchoalveolar lavage fluid provide insights into the inhaled corticosteroids treatment response in COPD.

ABSTRACT:

Background

Inhaled corticosteroids (ICS) are widely used to treat chronic obstructive pulmonary disease (COPD), but treatment responses vary among individuals. Identifying biomarkers that can improve our understanding of disease mechanisms and help predict ICS responsiveness is urgently needed. Extracellular vesicles (EVs), key mediators of intercellular communication, may offer novel insights and serve as a potential biomarker source.

Methods

34 COPD patients participated were treated for 6 months with either placebo or ICS (500 µg fluticasone ± 50 µg salmeterol). Lung function (FEV1% predicted, FEV1/FVC%, and RV/TLC% predicted) was assessed at baseline and 6 months. Proteins from BALF-derived EVs were analyzed at both time points using label-free quantitative proteomics. W

SUBMITTER: Fang J 

PROVIDER: S-EPMC12312508 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature