Role of vertebral fat fraction and R2* based on fat analysis and calculation technique in the quantitative assessment of osteoporosis.

ABSTRACT:

Purpose

To investigate the diagnostic efficacy of vertebral fat fraction (FF) and R2* derived from the Fat Analysis and Calculation Technique (FACT) for Osteoporosis (OP) and explore their associations with clinical parameters.

Methods

A total of 123 patients with low back pain (59.1 ± 15.1 years, 41males) underwent lumbar FACT magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA) within 48 h. FF, R2*, BMD, T-scores, and Z-scores were measured at L1-L4 vertebrae. Based on WHO criteria (T-score), subjects were categorized into normal (T ≥ - 1), osteopenia (- 2.5 < T < - 1), and OP (T ≤ - 2.5) groups. Statistical analyses included ANOVA, Pearson/Spearman correlations, and ROC curve analysis.

Results

The OP group exhibited significantly higher FF va

SUBMITTER: Wu F 

PROVIDER: S-EPMC12312511 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature