Triglyceride glucose-weight-adjusted waist index as a cardiovascular mortality predictor: incremental value beyond the establishment of TyG-related indices.

ABSTRACT:

Background

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, emphasizing the need for enhanced risk stratification tools. The triglyceride‒glucose-weight adjusted waist index (TyG-WWI), which integrates insulin resistance and central obesity, has emerged as a potential predictor, but its performance relative to traditional TyG-related indices (TyG, TyG-WC, TyG-WHtR) requires further validation.

Methods

We analyzed data from 24,255 participants in the National Health and Nutrition Examination Survey (NHANES, 1999-2018). Weighted Cox proportional hazards models were used to assess the associations between TyG-related indices and cardiovascular mortality. Restricted cubic splines (RCSs) with four knots were employed to explore dose‒response relation

SUBMITTER: Qiu J 

PROVIDER: S-EPMC12312566 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature