Mixed-dimensional fluid-structure interaction simulations reveal key mechanisms of cerebrospinal fluid dynamics in the spinal canal.

ABSTRACT: Cerebrospinal flow dynamics (CSF) plays a critical role in structural disorders of the central nervous system (CNS) and in the design of effective procedures for intrathecal drug delivery. Medical imaging techniques have only partially characterized CSF dynamics. Computational models have the potential to offer a high-resolution description of CSF flow and advance our mechanistic understanding. However, anatomically-accurate computational models of CSF dynamics in the spinal canal have largely ignored the compliance of the spinal tissues, which is critical to understand the pulse wave velocity and the craniocaudal decay of CSF pulsations. Here, we propose a mixed-dimensional fluid-structure interaction method that enables high-fidelity simulations of CSF dynamics on anatomically-accurate m

SUBMITTER: Putluru DR 

PROVIDER: S-EPMC12312592 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature