Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study.

ABSTRACT:

Background

Glucokinase activator (GKA) has shown potential in influencing cardio-cerebrovascular diseases (CVDs), yet its metabolic mechanism remains unclear. Circulating metabolites play a significant role in the etiology of CVDs. We hypothesized that the effects of GKA on cardio-cerebrovascular outcomes are mediated through circulating metabolites.

Methods

We selected genetic variants associated with GCK mRNA expression levels and HbA1c as genetic instruments for GKA. Data on 168 circulating metabolites measured by nuclear magnetic resonance spectroscopy, along with information on atrial fibrillation (AF), heart failure (HF), coronary artery disease (CAD), myocardial infarction (MI), and stroke, were retrieved from large-scale datasets. Using two-sample Mendelian randomiza

SUBMITTER: Wang X 

PROVIDER: S-EPMC12312601 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature