Neuropsychiatric symptoms predict rate of change in executive function in Alzheimer's disease and related dementias.

ABSTRACT:

Objective

Neuropsychiatric symptoms (NPS) are considered diagnostic and prognostic indicators of dementia and are attributable to neurodegenerative processes. Little is known about the prognostic value of early NPS on executive functioning (EF) decline in Alzheimer's disease and related dementias (ADRD). We examined whether baseline NPS predicted the rate of executive function (EF) decline among older adults with ADRD.

Method

Older adults (n = 1625) with cognitive impairment were selected from the National Alzheimer's Coordinating Center database. EF was estimated with a latent factor indicated by scores on Number Span Backward, Letter Fluency, and Trail Making-Part B. A curve of factors (CUFF) latent growth curve model was estimated to examine rate of change over fou

SUBMITTER: Goodwin GJ 

PROVIDER: S-EPMC12312697 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature