Regional and Layer Specific Retinal Capillary Red Blood Cell Velocimetry in Healthy Human Subjects.

ABSTRACT:

Purpose

To investigate retinal capillary and choriocapillaris red blood cell (RBC) velocity using optical coherence tomography angiography (OCTA)-based velocimetry in healthy human subjects.

Methods

This was a cross-sectional, observational study using a 1050-nm swept-source OCTA instrument with a new M-B scan protocol to obtain 2 × 2-mm2 volumes in the central, nasal, and temporal macula regions. An eigendecomposition-based analysis estimated the average mean frequency (MF) of moving particles in the radial peripapillary capillaries (RPCs), superficial retinal layer (SRL), deep retinal layer (DRL), and choriocapillaris (CC) in each region. MF is linearly proportional to RBC velocity. A linear mixed model evaluated the effect of retinal layer and region on MF.

Results

SUBMITTER: Aman S 

PROVIDER: S-EPMC12312764 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature