Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication.

ABSTRACT:

Background

The central nervous system's influence on cardiac function is well described; however, direct evidence for signaling from heart to brain remains sparse. Mice with cardiac-selective overexpression of adenylyl cyclase type 8 (TGAC8) display elevated heart rate/contractility and altered neuroautonomic surveillance.

Objectives

In this study the authors tested whether elevated adenylyl cyclase type 8-dependent signaling at the cardiac cell level affects brain activity and behavior.

Methods

A telemetry system was used to record electrocardiogram (ECG) and electroencephalogram (EEG) in TGAC8 and wild-type mice simultaneously. The Granger causality statistical approach evaluated variations in the ECG/EEG relationship. Mouse behavior was assessed via elevated plus m

SUBMITTER: Agrimi J 

PROVIDER: S-EPMC12312800 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature