Adequate pelvic lymph node dissection during radical cystectomy for muscle-invasive carcinoma urinary bladder: A systematic review and meta-analysis of randomized controlled trials comparing extended and limited lymph node dissection.

ABSTRACT:

Introduction

To compare the efficacy and safety of extended lymph node dissection (eLND) versus standard LND (sLND) in patients with bladder cancer undergoing radical cystectomy, focusing on overall survival (OS), recurrence-free survival (RFS), and complications, including symptomatic lymphoceles.

Materials and methods

A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched PubMed, MEDLINE, Embase, Scopus, and Cochrane databases for randomized controlled trials (RCTs) comparing eLND and sLND. The primary outcomes were OS and RFS, while secondary outcomes included complications such as lymphoceles, sepsis, and urinary tract infections. Data were extracted independently by tw

SUBMITTER: Madhavan K 

PROVIDER: S-EPMC12312837 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature