Spinal needles versus conventional needles for fine-needle aspiration biopsy of thyroid nodules-A multicenter randomized controlled trial.

ABSTRACT:

Objective

Ultrasound-guided fine-needle aspiration biopsy (FNAB) is essential for evaluating thyroid nodules but often yields inadequate samples, leading to repeated procedures, increased discomfort, and higher costs. Previous non-randomized studies found promising results of spinal needles to improve diagnostic adequacy. Therefore, we conducted a multicenter randomized controlled trial to validate these findings.

Methods

Between July 1st, 2021, and April 13th, 2023, patients with suspicious thyroid nodules were randomized to receive FNAB with either a 25G spinal needle or conventional needle. The primary outcome was the rate of adequate diagnostic cytology. Secondary outcomes included procedure-related pain, sensitivity and specificity of FNAB, and adverse events.

Result

SUBMITTER: Larsen KD 

PROVIDER: S-EPMC12312885 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature