Development and characterization of pramipexole dihydrochloride buccal films for Parkinson's disease treatment.

ABSTRACT: Parkinson's disease is one of the most common neurodegenerative diseases worldwide. Swallowing difficulties present a significant challenge in the treatment of Parkinson's disease patients. Our current experimental work aimed to produce and assess a buccal polymer film containing pramipexole as the active pharmaceutical agent. This dosage form addresses the swallowing difficulties faced by Parkinson's patients, potentially eliminating inappropriate drug application and thereby improving therapeutic success. For the preparation of polymer films, chitosan was used as the film-forming agent, and pramipexole dihydrochloride was the active pharmaceutical ingredient. The physical properties of the prepared polymer films, such as thickness, tensile strength, mass, and disintegration time were exa

SUBMITTER: Pamlenyi K 

PROVIDER: S-EPMC12312903 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature