Two mutations in NS2B are responsible for attenuation of the yellow fever virus (YFV) vaccine strain 17D.

ABSTRACT: Vaccines have done more to improve the health of humankind over the past century than almost any other technology. Among vaccines, the live-attenuated yellow fever (YF) vaccine (17D) is highly effective, providing long-lasting immunity against yellow fever virus (YFV) infection with a single dose. Developed in the 1930s through extensive serial passage of the virulent YFV-Asibi strain through mouse and chicken embryonic tissue, 17D acquired several mutations that render it attenuated in humans and non-human primates. Over the past century, 17D has become a widely studied immunogen and has also been developed into a vaccine platform for other pathogens. Despite this, most studies of 17D have focused exclusively on the host, without clearly defining the virus-intrinsic features of attenuatio

SUBMITTER: Qiu X 

PROVIDER: S-EPMC12312905 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature