Independent association of weight-adjusted waist index with asthma in U.S. adolescents: Mediating roles of eosinophil percentage, total cholesterol, and HDL cholesterol.

ABSTRACT:

Background

Obesity is a risk factor for asthma in adolescents. "Although body mass index (BMI) is the most widely used metric for assessing obesity, it has several limitations. The weight-adjusted waist index (WWI) is a novel central obesity indicator and accurately reflects body composition. We aimed to explore the association of WWI with asthma in adolescents using NHANES 1999-2020 data.

Methods

WWI was calculated based on waist circumference (cm) divided by the square root of weight (kg). Current asthma status in adolescents was determined based on participants' self-reports. Multivariate logistic regression analysis, restricted cubic spline (RCS) analysis, mediation analysis, and stratified analysis were used to comprehensively explore this association.

Results

A

SUBMITTER: He L 

PROVIDER: S-EPMC12312917 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature