Apparent differences between human and chimp proteomes are reduced when considering human population: Human specific variants are enriched in disordered and compositionally biased regions.

ABSTRACT: Humans exhibit significant differences from other primates in anatomy, physiology, behavior, and culture, despite having similar genomes. Understanding the genetic basis of these unique human traits has long been a goal of science and philosophy. Previous studies, including the comparison of the reference genomes, showed a high degree of sequence identity between the proteomes of humans and chimpanzees (Pan troglodytes), suggesting that differences may lie in gene regulation rather than protein function. To pinpoint human-specific protein mutations with possible relevance for human-specific traits, we went further in the study of human-chimp proteome differences by taking into account human genetic variation data from the Genome Aggregation Database (gnomAD) at protein-coding genes. We add

SUBMITTER: Mier P 

PROVIDER: S-EPMC12312948 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature