Evolution of strain diversity and virulence factor repertoire in pediatric Staphylococcus aureus isolates.

ABSTRACT:

Background

Invasive Staphylococcus aureus infections cause high morbidity and mortality in children and adults. With rising antimicrobial resistance, optimal prevention strategies and novel therapeutics are needed. As an effective vaccine remains elusive, characterization of invasive isolates over time is required to identify determinants of invasive infection.

Methods

S. aureus isolates recovered from children with invasive infection and those with colonization were obtained. Isolates were examined by whole genome sequencing to evaluate gene repertoire, sequence type, clonal complex, and phylogenetic characterization, and isolate characteristics were correlated to clinical data.

Results

118 children with invasive S. aureus infections were enrolled; 56% of infections

SUBMITTER: Free M 

PROVIDER: S-EPMC12312961 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature