Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice.

ABSTRACT: Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses. Microglia, the immune modulators within the brain, exhibit dual roles in exacerbating and ameliorating ischemic injury through neuroinflammatory and neuroprotective roles, respectively. Despite emerging insights into microglia's role in neuronal support, the potential of epigenetic intervention to modulate microglial activity remains largely unexplored. We have previously shown that sodium butyrate, a histone deacetylase inhibitor (HDACi) epigenetically regulates the inflammatory response of microglia after ischemic stroke, and this study was aimed at characterizing the transcriptomic profiles of microglia and their spatial distribution in the stroke brain following HDA

SUBMITTER: Jayaraj K 

PROVIDER: S-EPMC12313008 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature