Moderating effects of limbic white matter on verbal memory in older adults with multiple sclerosis.

ABSTRACT:

Objective

Literature concerning the structural brain correlates of verbal memory in aging with multiple sclerosis (MS) is scarce. This study addressed this gap by examining the impact of white matter microstructure and macrostructure on verbal memory in older adults with and without MS.

Method

Participants were 64 older adults with MS (OAMS; age M [SD] = 64.19 [3.82]) and 72 controls (age M [SD] = 69.78 [6.99]). Verbal memory was measured using the Hopkins Verbal Learning Test-Revised (HVLT-R), and white matter fractional anisotropy and lesion volume were extracted from diffusion tensor and fluid-attenuated inversion-recovery magnetic resonance imaging. Statistical models examined whether white matter measures moderated the association between the

SUBMITTER: Ross D 

PROVIDER: S-EPMC12313107 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature